Part ID: Vitamin K2 deficiency, dosage and supplementation
Vitamin K2 has recently gained popularity in smaller health circles for its many benefits. But are all Vitamin K2 supplements the same?
As a long term approach, I always recommend that my patients aim to get Vitamin K2 from food sources. However, if you can’t eat enough K2 rich foods or you have a certain condition, you may need to supplement your Vitamin K2.
Before choosing a Vitamin K2 supplement, you should understand that they’re not all the same.
Types of K2 supplements:
Vitamin K2 MK-4
MK-4 is the most active form of Vitamin K2 in the body, so any supplement should have some level of Vitamin K2 MK-4.
However, one problem with MK-4 K2 may be that it has a short plasma half-life. That means it’s quickly removed from the blood after consumption. Does that mean that Vitamin K2 MK-4 supplements are less effective?
Probably not. By definition, MK-4 Vitamin K2 should be removed quickly from the blood, as it’s rapidly taken up by tissues, organs, and the brain. Therefore, the short plasma half-life of MK-4 supplements does not make them less beneficial. MK-4 is stored in the arteries, pancreas and even salivary glands.
Vitamin K2 MK-7 supplement
There are no studies that compare the effects of MK-4 to MK-7.
The Vitamin K2 MK-7 is derived from bacteria. It is more likely to reach the bones and liver. We know it’s converted in the body to MK-4, but we don’t really know how much is converted.
Based on what we know currently, you should look for a supplement with BOTH Vitamin K2 MK-4 and MK-7.
Different Isomers of Vitamin K2 MK-7: Trans and CIS
There are two chemical isomers of MK-7: Trans and CIS.
The trans isomer is found in nature. CIS is not thought to be found in nature, so it might have a different action in the body.
Food sources of Vitamin K2 provide the trans form of MK-7.
If you get your K2 from foods, then great – this does not apply to you. But if you get it from supplements you need to be aware that packaging won’t often specify which isomer of K2 MK-7 is in the supplement.
Should I have Vitamin K1 with a Vitamin K2 supplement?
No, K1 is not critical to have K1 in a supplement. Nearly all of the benefits of K2 are from MK-4 K2 and MK-7
Most adults are not K1 deficient. Even consuming very small amounts of green leafy vegetables or vegetable oils can provide you with ample K1.
Vitamin K2 MK-4 has not revealed any established toxicity syndrome or risk of serious side effects.
Nevertheless, the biochemistry of Vitamin K suggests that unnecessarily high doses could rob the body of antioxidants or interfere with blood sugar regulation, insulin sensitivity, and hormonal health.
Can you take a Vitamin K2 supplement if you take warfarin?
This is critical if you are taking prescription anticoagulants such as warfarin:
The most common anticoagulants used in medicine are warfarin, Coumadin, and other brands of 4-hydroxycoumarins.
Vitamin K2 MK-7 can interfere with anticoagulation therapy when used above 50 μgm/day.
These anticoagulant drugs stop K1 recycling to keep the blood very thin. Taking these drugs keep you in an artificially K1 and K2 deficient state. So, if you’re taking these drugs, supplementing with K1 or K2 can make them ineffective.
Certain medications deplete K2 or inhibit its absorption:
- Warfarin or coagulants
- Broad spectrum antibiotics Vitamin K2 is also produced by gut bacteria in the large intestine, and there is some evidence that broad-spectrum antibiotics can contribute to K2 deficiency.
- Cholestyramine and colestipol, bile acid sequestrants
- Orlistat – a weight-loss drug which reduces absorption of fat-soluble vitamins, including vitamin K.
Who is at risk of Vitamin K2 deficiency?
Population-based studies and clinical trials have linked K-vitamin status in children to the creation of strong and healthy bones. A study published in 2008 showed that improving Vitamin-K status in children over a 2-year period resulted in stronger and denser bones. One year later, the same group of researchers showed that in healthy, pre-pubertal children, modest supplementation with Vitamin K2 MK-7 had increased activated bone forming osteocalcin.
In a 2013 published study, researchers tested 896 blood samples collected from 110 healthy volunteers, a group composed of 42 children and 68 adults. The researchers took measurements of biomarkers reflecting the volunteers’ Vitamin K2 status by measuring both circulating inactive MGP and inactive osteocalcin – proteins specific to heart and bone health, respectively. The researchers found that those children and adults with the most pronounced Vitamin K2 deficiency showed the highest responses to supplementation with MK-7. Children (and adults above the age of 40 years) showed the largest Vitamin K2 deficiency, and accordingly may benefit from MK-7 supplementation to improve their Vitamin K2 status.
How much vitamin K2 should I take in a day?
Vitamin K2 dosage for adults:
Between 100-300mcg per day is considered a standard dose. Dosages up to 600mcg per day for certain conditions may be necessary.
Vitamin K2 dosage for children:
45mcg per day should be a satisfactory dose for children under 12.
Vitamin K2 dosage for osteoporosis:
If you suffer from osteoarthritis you may need a dose of 200 mcg per day, up to 600mcg per day.
Sourcing and quality of vitamin K2 supplement:
Many brands buy their K2 from China or India.
Norwegian, American or Japanese-made K2 are preferable due to higher quality standards – call the company and enquire about the source of the material.
How much K2 should I take with D3?
Taking a Vitamin D3 supplement without K2 can have disastrous effect, as Vitamin D creates need for Vitamin K2 in the body.
As a guide, you should take 45mcg of Vitamin K2 per 1000 IU of Vitamin D3.
Take Vitamin D3 and K2 separately
Take your Vitamin K2 supplement with your dinner that includes dietary fat or at bedtime, 8 to 12 hours after you take your Vitamin D3.
Most people take their D3 with breakfast and K2 at dinner time and this seems sensible, as some research shows that D3 is more effective if not taken at the same time as K2.
Vitamin K2 MK-4 and Trans Mk-7 Vitamin K2 Supplement:
Innovix Vitamin K2 600mcg contains MK-4 + MK-7 and has a total of 600 mcg of K2 per capsule. The capsules are soy free and come in 90 capsule packs.
You can take one capsule every 3 days to get more than adequate vitamin K2.
Disclaimer: Information in this blog is intended for educational purposes only. There may be side effects related to any supplement or nutrient mentioned on this website. Please consult your medical professional before taking any supplement or food source of Vitamin K2. Links to Amazon may result in this website receiving a commission.
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- Theuwissen E et al. Vitamin K status in healthy volunteers. Food Funct. 2014 Feb;5(2):229-34
- van Summeren MJ et al. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr. 2009 Oct;102(8):1171-8.
- van Summeren M et al. Pronounced elevation of undercarboxylated osteocalcin in healthy children. Pediatr Res. 2007 Mar;61(3):366-70.